Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity in Intravenous Immunoglobulin as a Potential Therapeutic Against Emerging Influenza Viruses
Identifieur interne : 001110 ( Main/Exploration ); précédent : 001109; suivant : 001111Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity in Intravenous Immunoglobulin as a Potential Therapeutic Against Emerging Influenza Viruses
Auteurs : Sinthujan Jegaskanda [Australie] ; Kirsten Vandenberg [Australie] ; Karen L. Laurie [Australie] ; Liyen Loh [Australie] ; Marit Kramski [Australie] ; Wendy R. Winnall [Australie] ; Katherine Kedzierska [Australie] ; Steven Rockman [Australie] ; Stephen J. Kent [Australie]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2014.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Background. Intravenous immunoglobulin (IVIG) is a purified pool of human antibodies from thousands of donors that is used to prevent or treat primary immune deficiency, several infectious diseases, and autoimmune diseases. The antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) against heterologous influenza strains may be present in IVIG preparations. Methods. We tested 8 IVIG preparations prior to the 2009 H1N1 swine-origin influenza pandemic and 10 IVIG preparations made after 2010 for their ability to mediate influenza-specific ADCC. Results. ADCC mediating antibodies to A(H1N1)pdm09 hemagglutinin (HA) and neuraminidase (NA) were detected in IVIG preparations prior to the 2009-H1N1 pandemic. The HA-specific ADCC targeted both the HA1 and HA2 regions of A(H1N1)pdm09 HA and was capable of recognizing a broad range of HA proteins including those from recent avian influenza strains A(H5N1) and A(H7N9). The low but detectable ADCC recognition of A(H7N9) was likely due to rare individuals in the population contributing cross-reactive antibodies to IVIG. Conclusions. IVIG preparations contain broadly cross-reactive ADCC mediating antibodies. IVIG may provide at least some level of protection for individuals at high risk of severe influenza disease, especially during influenza pandemics prior to the development of effective vaccines.
Affiliations:
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Laurie</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>WHO Collaborating Centre for Reference and Research on Influenza, VIDRL</s1><s2>North Melbourne, Victoria</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>North Melbourne, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Loh, Liyen" sort="Loh, Liyen" uniqKey="Loh L" first="Liyen" last="Loh">Liyen Loh</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Kramski, Marit" sort="Kramski, Marit" uniqKey="Kramski M" first="Marit" last="Kramski">Marit Kramski</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Winnall, Wendy R" sort="Winnall, Wendy R" uniqKey="Winnall W" first="Wendy R." last="Winnall">Wendy R. Winnall</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Rockman, Steven" sort="Rockman, Steven" uniqKey="Rockman S" first="Steven" last="Rockman">Steven Rockman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>BioCSL Ltd</s1><s2>Parkville, Victoria</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>BioCSL Ltd</wicri:noRegion></affiliation></author><author><name sortKey="Kent, Stephen J" sort="Kent, Stephen J" uniqKey="Kent S" first="Stephen J." last="Kent">Stephen J. Kent</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne</s1><s3>AUS</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody-dependent cell cytotoxicity</term><term>IgA</term><term>Infection</term><term>Influenza</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Réaction ADCC</term><term>IgA</term><term>Infection</term><term>Grippe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Intravenous immunoglobulin (IVIG) is a purified pool of human antibodies from thousands of donors that is used to prevent or treat primary immune deficiency, several infectious diseases, and autoimmune diseases. The antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) against heterologous influenza strains may be present in IVIG preparations. Methods. We tested 8 IVIG preparations prior to the 2009 H1N1 swine-origin influenza pandemic and 10 IVIG preparations made after 2010 for their ability to mediate influenza-specific ADCC. Results. ADCC mediating antibodies to A(H1N1)pdm09 hemagglutinin (HA) and neuraminidase (NA) were detected in IVIG preparations prior to the 2009-H1N1 pandemic. The HA-specific ADCC targeted both the HA1 and HA2 regions of A(H1N1)pdm09 HA and was capable of recognizing a broad range of HA proteins including those from recent avian influenza strains A(H5N1) and A(H7N9). The low but detectable ADCC recognition of A(H7N9) was likely due to rare individuals in the population contributing cross-reactive antibodies to IVIG. Conclusions. IVIG preparations contain broadly cross-reactive ADCC mediating antibodies. IVIG may provide at least some level of protection for individuals at high risk of severe influenza disease, especially during influenza pandemics prior to the development of effective vaccines.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Jegaskanda, Sinthujan" sort="Jegaskanda, Sinthujan" uniqKey="Jegaskanda S" first="Sinthujan" last="Jegaskanda">Sinthujan Jegaskanda</name></region><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><name sortKey="Kent, Stephen J" sort="Kent, Stephen J" uniqKey="Kent S" first="Stephen J." last="Kent">Stephen J. Kent</name><name sortKey="Kramski, Marit" sort="Kramski, Marit" uniqKey="Kramski M" first="Marit" last="Kramski">Marit Kramski</name><name sortKey="Laurie, Karen L" sort="Laurie, Karen L" uniqKey="Laurie K" first="Karen L." last="Laurie">Karen L. Laurie</name><name sortKey="Loh, Liyen" sort="Loh, Liyen" uniqKey="Loh L" first="Liyen" last="Loh">Liyen Loh</name><name sortKey="Rockman, Steven" sort="Rockman, Steven" uniqKey="Rockman S" first="Steven" last="Rockman">Steven Rockman</name><name sortKey="Rockman, Steven" sort="Rockman, Steven" uniqKey="Rockman S" first="Steven" last="Rockman">Steven Rockman</name><name sortKey="Vandenberg, Kirsten" sort="Vandenberg, Kirsten" uniqKey="Vandenberg K" first="Kirsten" last="Vandenberg">Kirsten Vandenberg</name><name sortKey="Winnall, Wendy R" sort="Winnall, Wendy R" uniqKey="Winnall W" first="Wendy R." last="Winnall">Wendy R. Winnall</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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